Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… led to lower empirical antifungal treatment compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in empirical antifungal treatment compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in empirical antifungal treatment compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

More frequent (less than eight hours) vs less frequent (eight hours or greater) monitoring of gastric residual volume

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether more frequent (less than eight hours) changes mortality (at the end of compared with less frequent (eight hours or greater) monitoring of gastric… (very low certainty).

1 finding from 1 review

More frequent (less than eight hours) vs less frequent (eight hours or greater) monitoring of gastric residual volume

Pneumonia · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether more frequent (less than eight hours) changes pneumonia (until discontinued or up to 28 days) compared with less frequent (eight hours or greater) monitoring of gastric… (very low certainty).

1 finding from 1 review

No monitoring vs frequent monitoring (12 hours or less) of gastric residual volume

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether no monitoring changes mortality (at the end of compared with frequent monitoring (12 hours or less) of gastric residual volume (very low certainty).

1 finding from 1 review