Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Dropouts due to adverse events · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children with trichotillomania

Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania
1 finding from 1 review

Antipsychotics vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Antipsychotics may leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review