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Evidence found and GRADE certainty

1,550 questions · 1,617 findings · 161 reviews · Neonatal

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No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Adverse effects: contact dermatitis · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Silver‐alginate dressing vs control

CRBSI ‐ Unit of analysis: infants Clinical and microbiological methods · newborn infants with central venous catheters

Silver‐alginate dressing showed no clear difference in CRBSI ‐ Unit of analysis: infants Clinical and microbiological methods compared with control (moderate certainty).

1 finding from 1 review

Silver‐alginate dressing vs control

CRBSI ‐ Unit of analysis: catheters Clinial and microbiological methods · newborn infants with central venous catheters

Silver‐alginate dressing showed no clear difference in CRBSI ‐ Unit of analysis: catheters Clinial and microbiological… compared with control (moderate certainty).

1 finding from 1 review

Intervention not reported

CRBSI (confirmed) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower CRBSI (confirmed) Clinical and microbiological assessments (high certainty).

1 finding from 1 review

Intervention not reported

CRBSI (suspected) Clinical assessment · newborn infants who require a central venous catheter

The intervention showed no clear difference in CRBSI (suspected) Clinical assessment (moderate certainty).

1 finding from 1 review

Intervention not reported

Total CRBSI (confirmed and suspected) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower total CRBSI (confirmed and suspected) Clinical and microbiological… (high certainty).

1 finding from 1 review

Intervention not reported

Mortality Clinical assessment · newborn infants who require a central venous catheter

It is very uncertain whether the intervention changes mortality Clinical assessment (very low certainty).

1 finding from 1 review

Intervention not reported

Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level · newborn infants who require a central venous catheter

The intervention leads to lower number of infants with hypoglycaemia Blood sugar level: glucose… (high certainty).

1 finding from 1 review