Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,718 questions · 1,762 findings · 100 reviews · Headline outcomes only

No studies found 507 · 28.8%GRADE not reported 115 · 6.5%Very low 556 · 31.6%Low 444 · 25.2%Moderate 114 · 6.5%High 26 · 1.5%

Intervention not reported

Patient satisfaction · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Retention on treatment Duration of retention on treatment was not reported in these studies. The retention on treatment in this analysis is assessed by the number of withdrawals in the intervention and placebo groups The results show a trend in fa... · people with epilepsy and intellectual disability

The intervention showed no clear difference in retention on treatment Duration of retention on treatment was not… (moderate certainty).

1 finding from 1 review

Intervention not reported

Seizure freedom 1 study reported the incidence of seizure frequency in the intervention and placebo group The results show a trend in favour of the AED group · people with epilepsy and intellectual disability

The intervention showed no clear difference in seizure freedom 1 study reported the incidence of seizure frequency… (low certainty).

1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in overall seizure frequency) · people with epilepsy and intellectual disability

The intervention may leads to higher responder rate (≥ 50% reduction in overall seizure frequency) (low certainty).

1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in rate of drop seizures) · people with epilepsy and intellectual disability

The intervention showed no clear difference in responder rate (≥ 50% reduction in rate of drop seizures) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 4 studies reported the frequency of self reported adverse events in the AED and placebo groups The results show a trend in favour of the placebo groups · people with epilepsy and intellectual disability

The intervention showed no clear difference in adverse events 4 studies reported the frequency of self reported… (moderate certainty).

1 finding from 1 review

Intervention not reported

Although a higher percentage of people in the ATL and aCCT groups fell within Class I (seizure free) and Class II (> 50% reduction in seizures), no significant differences in seizure frequency were noted between the groups at 2 years after surgery... · people with temporal lobe epilepsy and intellectual disabilities
1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual aid (Passive) ICC = 0 (perfect vs. poor‐moderate compliance) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ 2 parents vs. 1 parent Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ 2 parents vs. 1 parent Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Parental presence vs. midazolam Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Parental presence vs. midazolam Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Low sensory stimulation vs. control (Passive) ICC = 0 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Low sensory stimulation vs. control… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Mask introduction/exposure (Mask) ICC (number of children compliant) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Mask introduction/exposure (Mask)… (very low certainty).

1 finding from 1 review

Intervention not reported

Anxiety during induction ‐ hypnosis vs. midazolam (Interactive) mYPAS < 24 · children

It is very uncertain whether the intervention changes anxiety during induction ‐ hypnosis vs. midazolam (Interactive)… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Acupuncture for parents Perfect induction ICC=0 · parents with children

The intervention may leads to higher co‐operation during induction ‐ Acupuncture for parents Perfect… (low certainty).

1 finding from 1 review