What do systematic reviews say?

Transradial vs transfemoral approach

Transradial probably leads to lower success of the procedure compared with transfemoral approach (moderate certainty).

• Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in… 2018 · Cochrane Headline outcomes only
  RR 0.97 [0.96, 0.98]
  28 studies · 25920 participants
  Moderate

Transradial vs transfemoral approach

Transradial leads to lower short‐term all‐cause mortality compared with transfemoral approach (high certainty).

• Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in… 2018 · Cochrane Headline outcomes only
  RR 0.77 [0.62, 0.95]
  10 studies · 18955 participants
  High

Transradial vs transfemoral approach

Transradial may leads to lower bleeding compared with transfemoral approach (low certainty).

• Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in… 2018 · Cochrane Headline outcomes only
  RR 0.54 [0.4, 0.74]
  20 studies · 23043 participants
  Low

Transradial vs transfemoral approach

Transradial may leads to lower access site complications compared with transfemoral approach (low certainty).

• Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in… 2018 · Cochrane Headline outcomes only
  RR 0.36 [0.22, 0.59]
  24 studies · 16112 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in relapse compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.94 [0.72, 1.24]
  9 studies · 804 participants
  Low
• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.74 [0.51, 1.07]
  7 studies · 742 participants
  Moderate
• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.74, 1.33]
  5 studies · 556 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in adverse events compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.64, 1.07]
  5 studies · 404 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 272 participants
  Moderate

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in symptom persistence compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.41 [0.14, 1.2]
  3 studies · 80 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in 24‐hour beta agonist use compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.54 [0.21, 1.37]
  2 studies · 48 participants
  Low

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

The review found no eligible studies for this question.

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SDAC vs no intervention

The review found no eligible studies for this question.

• First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SDAC + hospital intervention vs hospital intervention

• First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 3562 participants
  Very low

SDAC + hospital intervention vs hospital intervention

• First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  Low