What do systematic reviews say?

Arthroscopic surgery vs sclerosing injection

The review found no eligible studies for this question.

• Surgery for patellar tendinopathy (jumper’s knee) 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Preoperative radiotherapy vs surgery

Preoperative radiotherapy probably leads to lower overall mortality ( compared with surgery alone (moderate certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  Peto OR 0.9 [0.83, 0.98]
  4 studies · 4663 participants
  Moderate

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  Peto OR 0.97 [0.87, 1.08]
  2 studies · 3211 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in cause‐specific mortality ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  Peto OR 0.89 [0.77, 1.03]
  2 studies · 2145 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy probably leads to lower local recurrence ( compared with surgery alone (moderate certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  Peto OR 0.48 [0.4, 0.57]
  4 studies · 4663 participants
  Moderate

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in curative resection ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  RR 1 [0.97, 1.02]
  4 studies · 4673 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in sphincter preservation ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.94, 1.04]
  3 studies · 4379 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  RR 1.25 [1.04, 1.52]
  2 studies · 2698 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  RR 1.2 [1.01, 1.42]
  2 studies · 2698 participants
  Low

Preoperative radiotherapy vs surgery

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 3211 participants
  Low

Methionine and supportive treatment vs supportive treatment

It is very uncertain whether methionine and supportive treatment changes mortality compared with supportive treatment (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.14 [0, 6.82]
  1 study · 26 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.67 [0.11, 4.08]
  1 study · 202 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.3 [0.17, 0.53]
  1 study · 217 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.4 [0.22, 0.75]
  1 study · 203 participants
  Low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.39 [0.21, 0.7]
  1 study · 208 participants
  Low

Oral vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Very low

Oral vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes nausea compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.71 [1, 7.38]
  1 study · 66 participants
  Very low

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes vomiting compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.1 [0.62, 7.12]
  1 study · 66 participants
  Very low

Intravenous acetylcysteine vs placebo

Intravenous acetylcysteine may leads to lower mortality compared with placebo (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.29 [0.09, 0.94]
  1 study · 50 participants
  Low