Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Hypnosis vs relaxation

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Dental attendance · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
  • School dental screening programmes for oral health 2022 · Cochrane All outcomes
    3 to 4 months
    Data not pooled; 6281 participants (4 RCTs); Very low. There was substantial heterogeneity, in part due to study design (3 cluster-RCTs and 1 individually randomised trial). We are unable to draw conclusions about this…
    4 studies · 6281 participants
    Very low

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Quality of life indicators · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
1 finding from 1 review

Fluoride-releasing resin-based sealant vs Resin-based sealant

Retention of sealant (complete or partial retention) · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    6-24 months
    Effect estimate not calculable; 69 (2 studies). Retention equivocal: Unal 2015 100% (fluoride resin) vs 96.0% (resin) at 12 months; Baca 2007 84.1% (fluoride resin) vs 97.7% (resin) at 12 months; at 24 months 87.8% vs…
    2 studies · 69 participants
    Very low

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Plaque index (PI) / oral hygiene · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

Periodontal treatment (subgingival instrumentation, with or without… led to lower plaque index (PI) / oral hygiene compared with no active intervention/usual care; GRADE not reported.

1 finding from 1 review

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Probing pocket depth (PPD/PD) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

Periodontal treatment (subgingival instrumentation, with or without… led to lower probing pocket depth (PPD/PD) compared with no active intervention/usual care; GRADE not reported.

1 finding from 1 review

Mindfulness plus medication vs Medication alone

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Analgesic (painkiller) use · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes analgesic (painkiller) use compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Glass ionomer-based sealant vs No sealant (control/no treatment)

Retention of sealant (complete or partial retention) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    6-30 months
    Chadwick 2005: one or more sealants fully/partially retained in 69 (31.2%) children at 12-30 months; Joshi 2019: at 12 months 75 (43.6%) teeth completely retained, 58 (33.7%) partially retained, 39 (22.7%) completely…
    2 studies
    GRADE not reported

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at two weeks (postobturation) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

Single-visit root canal treatment showed no clear difference in pain at two weeks (postobturation) compared with multiple-visit root canal treatment (two or more visits); GRADE not reported.

1 finding from 1 review

Autopolymerised sealant vs Light polymerised sealant

Retention of sealant (complete or partial retention) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

It is very uncertain whether autopolymerised sealant changes retention of sealant (complete or partial retention) compared with light polymerised sealant (very low certainty).

1 finding from 1 review

Fluoride-releasing resin-based sealant vs No sealant (control/no treatment)

Retention of sealant (complete or partial retention) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    12-24 months
    At 12 months, sealants on 96 (70.1%) surfaces completely retained, 25 (18.3%) partially retained, 16 (11.6%) completely lost; at 24 months, 58 (45.3%) completely retained, 29 (22.7%) partially retained, 41 (32%)…
    1 study
    GRADE not reported

Criteria-based screening with specific (personalised) referral letter vs Criteria-based screening with non-specific referral letter

Dental attendance at orthodontist · School children, secondary school in the UK (aged 11 to 13 years)

It is very uncertain whether criteria-based screening with specific (personalised) referral letter changes dental attendance at orthodontist compared with criteria-based screening with non-specific referral letter (very low certainty).

1 finding from 1 review