Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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HFNC vs standard oxygen therapy

Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support

HFNC may leads to lower treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with standard oxygen therapy (low certainty).

1 finding from 1 review

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Use of conventional phototherapy, if sunlight (with or without filters or amplification) was first used for prevention or early treatmentc · infants with confirmed hyperbilirubinemia

The review found no eligible studies for this question.

1 finding from 1 review

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Hyperthermia while receiving sunlight or conventional phototherapyg · infants with confirmed hyperbilirubinemia

Sunlight (with or without filters or amplification) probably leads to higher hyperthermia while receiving sunlight or conventional phototherapyg compared with other sources of phototherapy (moderate certainty).

1 finding from 1 review

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Hypothermia while receiving sunlight or conventional phototherapyk · infants with confirmed hyperbilirubinemia

Sunlight (with or without filters or amplification) showed no clear difference in hypothermia while receiving sunlight or conventional phototherapyk compared with other sources of phototherapy (moderate certainty).

1 finding from 1 review

Supervised exercise therapy following vascular intervention vs vascular intervention alone

All‐cause mortality · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes mortality compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Supervised exercise therapy following vascular intervention vs vascular intervention alone

Reintervention · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes reintervention compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Combination therapy vs alpha‐blocker

Surgical intervention · men with lower urinary tract symptoms secondary to benign prostatic obstruction

It is very uncertain whether combination therapy changes surgical intervention compared with alpha‐blockers (very low certainty).

1 finding from 1 review