Periodontal disease (gingivitis/periodontitis) · Children or adolescents
CLWH on ART had significantly higher prevalence of periodontal disease than healthy controls (pooled OR 3.11, 95% CI 1.62 to 5.97; moderate heterogeneity).
1 finding from 1 review
Dental caries prevalence · Children or adolescents
In permanent dentition, CLWH on ART had higher caries prevalence than healthy controls (OR 2.49, 95% CI 1.86 to 3.32; single study).
3 findings from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · Permanent dentition (DMFT > 0)
OR 2.49 [1.86, 3.32]
1 study · 724 participants
GRADE not reported
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal)
OR 2.70 [2.01, 3.62]
2 studies · 1028 participants
GRADE not reported
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · Primary dentition (dmft > 0)
OR 1.93 [1.34, 2.79]
1 study · 564 participants
GRADE not reported
Mucocele · Children or adolescents
No significant difference in mucocele between groups (OR 3.03, 95% CI 0.12 to 75.37; single study).
1 finding from 1 review
Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents
No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.
1 finding from 1 review
Chronic herpes simplex infection (WHO clinical stage 4) · Children or adolescents
No eligible studies reported chronic herpes simplex infection.
1 finding from 1 review
Poor (inadequate) oral hygiene (prevalence) · Children or adolescents
No significant difference in oral hygiene between CLWH on ART and healthy controls (OR 1.23, 95% CI 0.73 to 2.07; single study).
1 finding from 1 review
Persistent parotid enlargement (WHO clinical stage 2) · Children or adolescents
No significant difference in persistent parotid enlargement between groups (OR 10.36, 95% CI 0.53 to 201.45; single study, very imprecise).
1 finding from 1 review
Oral hairy leukoplakia (WHO clinical stage 3) · Children or adolescents
No difference in oral hairy leukoplakia between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); lesion essentially absent in both.
1 finding from 1 review
Angular cheilitis (WHO clinical stage 2) · Children or adolescents
No significant difference in angular cheilitis prevalence between CLWH and healthy controls (pooled OR 1.95, 95% CI 0.16 to 23.65).
1 finding from 1 review
Oral candidiasis (WHO clinical stage 3) · Children or adolescents
CLWH on ART had markedly higher prevalence of oral candidiasis than healthy controls (pooled OR 16.94, 95% CI 5.06 to 56.70).
1 finding from 1 review
Linear gingival erythema (WHO clinical stage 2) · Children or adolescents
No difference in linear gingival erythema between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); the lesion was essentially absent in both groups.
1 finding from 1 review
Dental caries (by severity) · Children or adolescents
One study reported higher median caries severity among CLWH under 12 years; no meta-analytic estimate was pooled.
1 finding from 1 review
Number of minor postoperative bleeding episodes · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
The review found no eligible studies for this question.
1 finding from 1 review
Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)
Outcome not reported · People with Von Willebrand disease undergoing minor oral surgery or dental extractions
The review found no eligible studies for this question.
1 finding from 1 review
Major bleeding, requiring transfusion of packed red blood cells · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review
Change in haemoglobin level from baseline · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review
Mean fall in haemoglobin. Forbes (TXA): 1.4 g/100 mL (placebo) vs 0.3 g/100 mL (TXA). Walsh (EACA): 6.3% (placebo, both centres) vs 3.9% and 3.7% (EACA, centres 1 and 2); differences not significant. Reported in…
2 studies · 59 participants
GRADE not reported
Bleeding duration · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
The review found no eligible studies for this question.
1 finding from 1 review
Need for and dose of clotting factor concentrates · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review
Reported in both trials in different ways. Forbes (TXA): mean units of replacement therapy per root extracted 617 IU (range 0 to 15,800) in 11 placebo participants versus 30 IU and 65 IU per root in 2 TXA participants…
2 studies · 59 participants
GRADE not reported
Any postoperative complication except bleeding (e.g. wound infection) · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
The review found no eligible studies for this question.
1 finding from 1 review
Number of postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… probably leads to lower number of postoperative bleeding episodes requiring intervention compared with placebo, no intervention or usual care (with or without placebo) (moderate certainty).
1 finding from 1 review