Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

Specific behaviour: aggression ‐ important decrease in aggression · people with long‐term aggression in psychosis

HALOPERIDOL leads to lower specific behaviour: aggression ‐ important decrease in aggression compared with OTHER ANTIPSYCHOTICS (high certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

Specific behaviour ‐ threat or injury to self or others average change score (ABS, high = worse) at 2 hours · people with long‐term aggression in psychosis

HALOPERIDOL leads to lower specific behaviours ‐ threat or injury to others/self compared with OTHER ANTIPSYCHOTICS (high certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR versus various controls · participants at risk of developing long‐term conditions

The review found no eligible studies for this question.

1 finding from 1 review