Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · All outcomes

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: oral breathing (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: oral breathing (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Preoperative analgesics (analgesics given before dental treatment) vs Placebo or no analgesics

Patient satisfaction · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Improvement on sagittal relationship between the maxilla and mandible (cephalometric data) · Children with obstructive sleep apnoea (aged 15 years or younger)

The review found no eligible studies for this question.

1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Need for anaesthesia · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) led to lower need for anaesthesia compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.

2 findings from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Nocturnal symptom: restless sleep (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes nocturnal symptom: restless sleep (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Intervention not reported

Dental caries prevalence in permanent teeth (cavitated lesions) · Children aged 11-13 years in Latin America and the Caribbean

About 58% of 11-13 year-old children in Latin America and the Caribbean had dental caries in permanent teeth (95% CI 54-61%); certainty not graded.

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Oral health-related quality of life · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

The review found no eligible studies for this question.

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: nasal stuffiness (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: nasal stuffiness (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: school problems (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: school problems (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Intravenous analgesia

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Plaque · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Educational intervention with information and practical components… showed no clear difference in dental plaque compared with (Optimised) usual care (low certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Oral health: Not having seen a dentist in the past year · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Caries development in permanent teeth · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

Initiation of water fluoridation (artificial or natural) may leads to lower caries in permanent teeth (change in DMFT) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).

1 finding from 1 review

Glass ionomer sealant (with fluoride gel plus dentifrice) vs Fluoride gel plus fluoride toothpaste/dentifrice (non-invasive control)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.

1 finding from 1 review

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals of all ages

Individuals with Down syndrome had a lower mean DMFT in permanent teeth than controls (pooled SMD -0.18, 95% CI -0.35 to -0.02; 6 studies; I2=20%); certainty of evidence not graded.

1 finding from 1 review

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Participant and operator perception · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

The review found no eligible studies for this question.

1 finding from 1 review

Adhesive/polyurethane sealant patch vs No treatment (both arms received flossing plus fluoride toothpaste)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Adhesive/polyurethane sealant patch showed no clear difference in caries (lesion) progression (radiographic) compared with no treatment (both arms received flossing plus fluoride toothpaste); GRADE not reported.

1 finding from 1 review