Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,908 questions · 3,101 findings · 509 reviews

No studies found 571 · 18.4%GRADE not reported 358 · 11.5%Very low 723 · 23.3%Low 854 · 27.5%Moderate 489 · 15.8%High 106 · 3.4%

Intervention not reported

Pain intensity various scales short‐term · adults with chronic low‐back pain
1 finding from 1 review

Intervention not reported

Pain intensity various scales intermediate‐term · adults with chronic low‐back pain
1 finding from 1 review

Intervention not reported

Other outcomes [2] (continuous outcomes) Smoking, dementia, obesity, hypertension, insomnia, anxiety, asthma, phobia)
1 finding from 1 review

Intervention not reported

Sharp reduction of 5 km/h in median speed on experimental roads after program launch. No further reduction observed despite intensified enforcement. However reduction sustained throughout the 15 month trial period.
1 finding from 1 review

Intervention not reported

Pain intensity Various validated pain scales · Patients with osteoarthritis of the knee

The intervention showed no clear difference in pain intensity Various validated pain scales (low certainty).

1 finding from 1 review

Intervention not reported

Pain intensity Various validated pain scales · Patients with osteoarthritis of the knee

The intervention showed no clear difference in pain intensity Various validated pain scales (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes adverse effects ‐ cardiovascular ‐ hypotension compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

Oral celecoxib (COX-2 inhibitor) vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral celecoxib (COX-2 inhibitor) showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Naproxen vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral naproxen (NSAID) led to lower pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review