Cochrane · systematic review · CD003974

Placebo interventions for all clinical conditions

Hróbjartsson, A, Gøtzsche, PC · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library

Consumers and CommunicationAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Effect of placebo interventions across all clinical conditions (main findings)

6 questions
OutcomeEffectEvidenceStatus / GRADE
All clinical conditions (binary outcomes)
no estimate extracted44 studies · 6041 participantsModerate
All clinical conditions (continuous outcomes)
no estimate extracted158 studies · 10525 participantsModerate
Pain [2] (continuous outcomes)
no estimate extracted60 studies · 4154 participantsModerate
Nausea [2] (continuous outcomes) Â
no estimate extracted7 studies · 452 participantsModerate
Depression [2] (continuous outcomes)
no estimate extracted8 studies · 324 participantsModerate
Other outcomes [2] (continuous outcomes) Smoking, dementia, obesity, hypertension, insomnia, anxiety, asthma, phobia)
no estimate extracted41 studies · 1317 participantsLow