Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,549 questions · 1,604 findings · 181 reviews

No studies found 258 · 16.1%GRADE not reported 69 · 4.3%Very low 337 · 21%Low 406 · 25.3%Moderate 410 · 25.6%High 124 · 7.7%

Intervention not reported

Mortality · acute bacterial meningitis

The intervention showed no clear difference in mortality (moderate certainty).

1 finding from 1 review

Intervention not reported

Severe hearing loss · acute bacterial meningitis

The intervention leads to lower severe hearing loss (high certainty).

1 finding from 1 review

Intervention not reported

Any hearing loss · acute bacterial meningitis

The intervention leads to lower any hearing loss (high certainty).

1 finding from 1 review

Intervention not reported

Short‐term neurological sequelae · acute bacterial meningitis

The intervention showed no clear difference in short‐term neurological sequelae (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ recurrent fever · acute bacterial meningitis

The intervention probably leads to higher adverse events ‐ recurrent fever (moderate certainty).

1 finding from 1 review

Intervention not reported

Seizure frequency: Two out of five children had some improvement in seizure frequency. One child has unchanged seizure frequency and one child withdrew from the study and other had Infantile spasm. · children with intractable seizures
1 finding from 1 review