Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Ventilation tubes vs no treatment

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether ventilation tubes changes adverse event: persistent perforation Randomised by ear, assumed CC… compared with no treatment (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes hearing ‐ return to normal hearing Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes presence/persistence of OME Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes adverse event: persistent perforation compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Intervention not reported

Nicotine tapering · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in nicotine tapering (low certainty).

1 finding from 1 review

Intervention not reported

Nicotine patch · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in nicotine patch (low certainty).

1 finding from 1 review

Intervention not reported

Fast‐acting NRT (nicotine other) · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in fast‐acting NRT (nicotine other) (low certainty).

1 finding from 1 review