Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic placement failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in anaesthetic placement failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Intervention not reported

Overall survival (OS) · HER2‐positive early breast cancer patients

The intervention leads to lower overall survival (OS) (high certainty).

1 finding from 1 review

Intervention not reported

Disease free survival (DFS) · HER2‐positive early breast cancer patients

The intervention leads to lower disease free survival (DFS) (high certainty).

1 finding from 1 review

Intervention not reported

Congestive heart failure (CHF) · HER2‐positive early breast cancer patients

The intervention leads to higher congestive heart failure (CHF) (high certainty).

1 finding from 1 review

Intervention not reported

Left ventricular ejection fraction decline (LVEF) · HER2‐positive early breast cancer patients

The intervention probably leads to higher left ventricular ejection fraction decline (LVEF) (moderate certainty).

1 finding from 1 review

Intervention not reported

Brain metastasis as first site of relapse · HER2‐positive early breast cancer patients

The intervention may leads to higher brain metastasis as first site of relapse (low certainty).

1 finding from 1 review

Intervention not reported

Death within 5 years · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in death within 5 years (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression within 5 years · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention probably leads to lower disease progression within 5 years (moderate certainty).

1 finding from 1 review

Intervention not reported

Haematological adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in haematological adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review

Intervention not reported

Gastrointestinal adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in gastrointestinal adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review

Intervention not reported

Genitourinary adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in genitourinary adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review