Any postoperative complication except bleeding (e.g. wound infection) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in any postoperative complication except bleeding (e.g. wound infection) compared with placebo (placebo solution/mouthwash); GRADE not reported.
1 finding from 1 review
Number of participants with postoperative bleedings requiring intervention · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… probably leads to lower number of participants with postoperative bleedings requiring… compared with placebo (placebo solution/mouthwash) (moderate certainty).
1 finding from 1 review
Amount of postoperative blood loss (mL) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Intervention not reported
Mean total blood transfused (mL): tranexamic acid vs placebo · children undergoing surgery for scoliosis
1 finding from 1 review
Intervention not reported
Mean total blood loss (mL): tranexamic acid vs placebo · children undergoing surgery for scoliosis
1 finding from 1 review
Intervention not reported
Mean total blood loss (mL): aminocaproic acid vs tranexamic acid · children undergoing surgery for scoliosis
1 finding from 1 review
Intervention not reported
Number of participants receiving blood transfusion: tranexamic acid vs placebo · children undergoing surgery for scoliosis
It is very uncertain whether the intervention changes number of participants receiving blood transfusion: tranexamic acid… (very low certainty).
1 finding from 1 review
Intravenous injection of tranexamic acid · women with uterine fibroids
Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in intravenous injection of tranexamic acid compared with placebo or no treatment (low certainty).
1 finding from 1 review
Blood loss ‐ Tranexamic acid versus control (litre) · Patients with liver transplantation.
1 finding from 1 review
Blood loss ‐ Tranexamic acid versus aprotinin · Patients with liver transplantation.
1 finding from 1 review
Blood transfusion (red cell or whole blood) · Patients with liver transplantation.
2 findings from 1 review
60‐day mortality ‐ Tranexamic acid versus control · Patients with liver transplantation.
It is very uncertain whether intervention changes 60‐day mortality ‐ Tranexamic acid versus control compared with control (very low certainty).
1 finding from 1 review
60‐day mortality ‐ Tranexamic acid versus aprotinin · Patients with liver transplantation.
It is very uncertain whether intervention changes 60‐day mortality ‐ Tranexamic acid versus aprotinin compared with control (very low certainty).
1 finding from 1 review
Retransplantation ‐ Tranexamic acid versus control · Patients with liver transplantation.
It is very uncertain whether intervention changes retransplantation ‐ Tranexamic acid versus control compared with control (very low certainty).
1 finding from 1 review
Thromboembolic events · Patients with liver transplantation.
It is very uncertain whether intervention changes thromboembolic episodes ‐ Tranexamic acid versus control compared with control (very low certainty).
1 finding from 1 review
Intervention not reported
Total studies: 47 Total participants: 4398 · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
47 participants
GRADE not reported
Intervention not reported
TXA given intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
2 participants
Low
Intervention not reported
TXA given intravenously at a total dose of 1 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
1 participants
Low
Intervention not reported
TXA given orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
3 participants
Very low
Intervention not reported
TXA given orally at a total dose of 2 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
2 participants
Low