Cochrane · systematic review · CD006883
Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children
McNicol, ED, Tzortzopoulou, A, Schumann, R, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 43.8%Low 9 · 56.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mean total blood loss (mL)
Population: children undergoing surgery for scoliosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean total blood loss (mL: antifibrinolytics vs placebo | no estimate extracted | 5 studies · 207 participants | Low Downgraded: risk of bias |
Mean total blood loss (mL): aminocaproic acid vs placebo | no estimate extracted | 1 study · 36 participants | Low Downgraded: risk of bias |
Mean total blood loss (mL): aprotinin vs placebo | no estimate extracted | 2 studies · 87 participants | Low Downgraded: risk of bias |
Mean total blood loss (mL): tranexamic acid vs placebo | no estimate extracted | 2 studies · 84 participants | Low Downgraded: risk of bias |
Mean total blood loss (mL): aminocaproic acid vs tranexamic acid | no estimate extracted | 1 study · 44 participants | Low Downgraded: risk of bias, imprecision |
Number of participants receiving blood transfusion
Population: children undergoing surgery for scoliosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants receiving blood transfusion: antifibrinolytics vs placebo | RR 0.65 [0.5, 0.85] | 4 studies · 195 participants | Very low Downgraded: risk of bias, publication bias |
Number of participants receiving blood transfusion: aminocaproic acid vs placebo | RR 0.48 [0.3, 0.76] | 2 studies · 108 participants | Very low Downgraded: risk of bias, publication bias |
Number of participants receiving blood transfusion: aprotinin vs placebo | RR 0.75 [0.44, 1.27] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
Number of participants receiving blood transfusion: tranexamic acid vs placebo | RR 0.85 [0.56, 1.3] | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision |
Number of participants receiving transfusion with allogeneic blood
Population: children undergoing surgery for scoliosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants receiving transfusion with allogeneic blood: antifibrinolytics vs placebo | RR 0.11 [0.01, 1.73] | 2 studies · 79 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Number of participants receiving transfusion with allogeneic blood: aminocaproic acid vs placebo | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias |
Number of participants receiving transfusion with allogeneic blood: aprotinin vs placebo | RR 0.11 [0.01, 1.73] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
Mean total volume of blood transfused (mL)
Population: children undergoing surgery for scoliosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean total blood transfused (mL): antifibrinolytics vs placebo | no estimate extracted | 5 studies · 207 participants | Low Downgraded: risk of bias |
Mean total blood transfused (mL): aminocaproic acid vs placebo | no estimate extracted | 1 study · 36 participants | Low Downgraded: risk of bias |
Mean total blood transfused (mL): aprotinin vs placebo | no estimate extracted | 2 studies · 87 participants | Low Downgraded: risk of bias |
Mean total blood transfused (mL): tranexamic acid vs placebo | no estimate extracted | 2 studies · 84 participants | Low Downgraded: risk of bias |