Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

193 questions · 205 findings · 27 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 46 · 22.4%GRADE not reported 4 · 2%Very low 54 · 26.3%Low 50 · 24.4%Moderate 35 · 17.1%High 16 · 7.8%

Intervention not reported

Number of transfused units of red blood cell (RBC) · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in number of transfused units of red blood cell (RBC) (low certainty).

1 finding from 1 review

Intervention not reported

Rate of RBC transfusion (total number of participants who required at least one unit of red blood cell transfusion) Time: perioperative and postoperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in rate of RBC transfusion (total number of participants who required… (low certainty).

1 finding from 1 review

Intervention not reported

Rate of plasma transfusion (total number of participants who required at least one unit of plasma transfusion) Time: perioperative and postoperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in rate of plasma transfusion (total number of participants who… (low certainty).

1 finding from 1 review

Intervention not reported

Reoperation (Number of participants with at least one reoperation) Time: perioperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes reoperation (Number of participants with at least one reoperation)… (very low certainty).

1 finding from 1 review

Intervention not reported

Readmission (Number of participants with at least one readmission) Time: perioperative periods) · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes readmission (Number of participants with at least one readmission)… (very low certainty).

1 finding from 1 review

Intervention not reported

Venous thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes venous thromboembolic events (number of participants with at least… (very low certainty).

1 finding from 1 review

Intervention not reported

Arterial thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes arterial thromboembolic events (number of participants with at least… (very low certainty).

1 finding from 1 review

Interferon + chemotherapy vs chemotherapy alone

Adverse event (flu‐like symptoms) · Women with advanced (Stage II‐IV) epithelial ovarian cancer who have undergone surgery

Interferon + chemotherapy showed no clear difference in adverse event (flu‐like symptoms) compared with chemotherapy alone (low certainty).

1 finding from 1 review