Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Diarrhoea · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether rice fortified with iron alone or in combination with other… changes diarrhoea (as defined by study authors) compared with unfortified rice (no micronutrients added) (very low certainty).

1 finding from 1 review

Pentoxifylline (oral 400 mg thrice daily) plus meglumine antimoniate (IMMA) (20 mg/ kg /day for 20 days) vs IMMA plus placebo

Complete cure, at least 3 months after the end of treatment · People with American cutaneous leishmaniasis

Pentoxifylline (oral 400 mg thrice daily) plus meglumine antimoniate… showed no clear difference in complete cure, at least 3 months after the end of treatment compared with IMMA plus placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Extrauterine growth restriction at discharge · preterm infants

Summary of findings table ‐ Re‐feeding showed no clear difference in risk of extrauterine growth restriction at discharge compared with discarding gastric residuals (low certainty).

1 finding from 1 review

Foam sclerotherapy vs placebo

Residual varicose veins · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes residual varicose veins compared with placebo (very low certainty).

1 finding from 1 review

Opioid antagonists vs placebo

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) & NIMH Trichotillomania Severity Scale (NIMH‐TSS) (no. of responders as > 50% reduction) · adults with trichotillomania

It is very uncertain whether opioid antagonists changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review