Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

625 questions · 647 findings · 67 reviews · Pregnancy and Childbirth

No studies found 83 · 12.8%GRADE not reported 70 · 10.8%Very low 141 · 21.8%Low 227 · 35.1%Moderate 97 · 15%High 29 · 4.5%

Oral misoprostol vs placebo/no treatment

Uterine hyperstimulation with fetal heart rate changes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation with fetal heart rate changes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Uterine hyperstimulation without fetal heart rate changes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Apgar score less than 7 at 5 minutes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes apgar score less than 7 at 5 minutes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Neonatal death (baby born alive at any gestation and dies within 28 days) · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids leads to lower neonatal death (infants born with signs of life who die within the… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Respiratory distress syndrome · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids leads to lower respiratory distress syndrome№ of participants: 11,183(26 RCTs) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Intraventricular haemorrhage · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Developmental delay in childhood№ of participants: 600 (3 RCTs). Age at · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids probably leads to lower developmental delay in childhood№ of participants: 600 (3 RCTs). Age… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review