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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

275 questions · 298 findings · 28 reviews · Dementia and Cognitive Improvement

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No studies found 47 · 15.8%GRADE not reported 9 · 3%Very low 45 · 15.1%Low 60 · 20.1%Moderate 104 · 34.9%High 33 · 11.1%

Souvenaid vs placebo

Combined cognitive‐functional outcome · Apathy in people with mild‐to‐moderate Alzheimer's disease
1 finding from 1 review

Souvenaid vs placebo

Any adverse events · Apathy in people with mild‐to‐moderate Alzheimer's disease

Souvenaid showed no clear difference in any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Souvenaid vs placebo

Any adverse event · People with MCI/prodromal AD

Souvenaid showed no clear difference in any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher clinician‐rated global impression tests (improved compared with… compared with placebo (moderate certainty).

1 finding from 1 review