Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

163 questions · 169 findings · 42 reviews

No studies found 29 · 17.2%GRADE not reported 8 · 4.7%Very low 29 · 17.2%Low 45 · 26.6%Moderate 52 · 30.8%High 6 · 3.6%

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Asthma relapse1at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in asthma relapse1at 20 to 24 days compared with oral corticosteroid (high certainty).

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Hoarseness at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hoarseness at 20 to 24 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Formoterol vs short‐acting beta2‐agonist

Exacerbations requiring oral corticosteroids ‐ adults · people with asthma

Formoterol probably leads to lower patients with an exacerbation requiring a course of oral… compared with short‐acting beta2‐agonist (moderate certainty).

1 finding from 1 review

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Respiratory distress syndrome · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes respiratory distress syndrome compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Necrotising enterocolitis · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes necrotising enterocolitis compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review