Adverse events (moderate) · adolescent and adult male circumcisions
Circumcision devices showed no clear difference in moderate adverse events compared with standard surgical techniques (low certainty).
1 finding from 1 review
Moderate to severe hypoxic‐ischaemic encephalopathy (HIE) · non‐vigorous neonates born through meconium‐stained amniotic fluid
It is very uncertain whether tracheal suction changes moderate to severe hypoxic‐ischaemic encephalopathy (HIE) compared with no tracheal suction (very low certainty).
1 finding from 1 review
Persistent moderate to severe symptoms at 12 to 24 weeks · adults (> 18 years of age) with trigger finger
NSAID injection may leads to higher persistent moderate to severe symptoms at 12 to 24 weeks compared with glucocorticoid injection (low certainty).
1 finding from 1 review
Number of people experiencing at least 1 exacerbation/moderate to severe exacerbation · patients with chronic obstructive pulmonary disease
It is very uncertain whether multi‐component interventions (with telehealth as a component of care) changes number of people experiencing at least 1 exacerbation/moderate to… compared with usual care (very low certainty).
1 finding from 1 review
Intervention not reported
Total daily moderate‐to‐vigorous physical activity (MVPA) · health problem or population
1 finding from 1 review
Exacerbations: number of people experiencing moderate or severe exacerbations · COPD
It is very uncertain whether multi‐component intervention changes exacerbations: number of people experiencing moderate or severe… compared with control (very low certainty).
1 finding from 1 review
Number of responders ‐ mild to moderate disease (12 weeks) · IBD patients
IV ferric carboxymaltose showed no clear difference in number of responders ‐ mild to moderate disease (16 weeks) compared with oral iron sulphate (low certainty).
1 finding from 1 review
Serious adverse events ‐ mild to moderate disease (16 weeks) · IBD patients
It is very uncertain whether IV ferric carboxymaltose changes serious adverse events ‐ mild to moderate disease (16 weeks) compared with oral iron sulphate (very low certainty).
1 finding from 1 review
Serious adverse events ‐ mild to moderate disease (16 weeks) · IBD patients
It is very uncertain whether IV iron sucrose changes serious adverse events ‐ mild to moderate disease (20 weeks) compared with oral iron sulphate (very low certainty).
1 finding from 1 review
Number of responders ‐ mild to moderate disease (12 weeks) · IBD patients
IV ferric carboxymaltose probably leads to higher number of responders ‐ mild to moderate disease (12 weeks) compared with IV iron sucrose (moderate certainty).
1 finding from 1 review
Serious adverse events ‐ mild to moderate disease (12 weeks) · IBD patients
It is very uncertain whether IV ferric carboxymaltose changes serious adverse events ‐ mild to moderate disease (12 weeks) compared with IV iron sucrose (very low certainty).
1 finding from 1 review
Pain frequency or change in pain frequency · people with inflammatory bowel disease
1 finding from 1 review
Dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with 24-month recall showed no clear difference in dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) compared with clinical examination with 6-month recall (low certainty).
1 finding from 1 review
Adverse effects: moderate to severe Infusion reactions · SSNS in children
Rituximab may leads to higher adverse effects: moderate to severe Infusion reactions compared with placebo or control (low certainty).
1 finding from 1 review
Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin
Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).
1 finding from 1 review
Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin
Imiquimod showed no clear difference in pain (moderate/severe) compared with surgical excision (low certainty).
1 finding from 1 review
Frequency, severity or duration of painful crises · people with SCD
1 finding from 1 review
no estimate extracted
70 participants
Low
Intervention not reported
Chronic lung disease ‒moderate to severe BPD · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room
It is very uncertain whether the intervention changes chronic lung disease ‒moderate to severe BPD (very low certainty).
1 finding from 1 review
RR 0.89 [0.33, 2.37]
1 study · 7 participants
Very low
Chronic lung disease ‐ moderate to severe BPD · preterm infants resuscitated by PPV at birth
Use of initial sustained inflation showed no clear difference in chronic lung disease ‒moderate to severe BPD compared with standard inflations (moderate certainty).
1 finding from 1 review
Perineal pain within 24 hours of giving birth ‐ Moderate + severe pain · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth
It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes perineal pain within 24 hours of giving birth ‐ Moderate + severe pain compared with no treatment (very low certainty).
1 finding from 1 review