Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

510 questions · 533 findings · 60 reviews

No studies found 153 · 28.7%GRADE not reported 18 · 3.4%Very low 134 · 25.1%Low 123 · 23.1%Moderate 80 · 15%High 25 · 4.7%

Imiquimod vs placebo

Response to treatment at 5 to 6 months ‐ overall response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to higher response to treatment at 5 to 6 months ‐ overall response compared with placebo (high certainty).

1 finding from 1 review

Imiquimod vs placebo

Complete response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to higher response to treatment at 5 to 6 months ‐ complete response compared with placebo (high certainty).

2 findings from 1 review

Imiquimod vs placebo

Response to treatment at 12 months ‐ overall response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod probably leads to higher response to treatment at 12 months ‐ overall response compared with placebo (moderate certainty).

1 finding from 1 review

Imiquimod vs cidofovir

Response to treatment at 6 months ‐ overall response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in response to treatment at 6 months ‐ overall response compared with cidofovir (moderate certainty).

1 finding from 1 review

Heliox vs placebo or no treatment

Proportion of children re‐presenting for medical care for ongoing croup symptoms (return to care) · children with croup

Heliox showed no clear difference in proportion of children re‐presenting for medical care for ongoing… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Cognitive behavioural therapy as vs standard‐of‐care therapy

Reduction in physical signs Decrease in seizure frequency End of treatment · people with conversion disorder according to DSM‐IV or ICD‐10 criteria

It is very uncertain whether cognitive behavioural therapy as changes reduction in physical signs Reduction in monthly seizure frequency… compared with standard medical care (very low certainty).

2 findings from 1 review

Cognitive behavioural therapy as vs standard‐of‐care therapy

Reduction in physical sign Seizure freedom as assessed by a daily self‐reported seizure diary End of treatment · people with conversion disorder according to DSM‐IV or ICD‐10 criteria

It is very uncertain whether cognitive behavioural therapy as changes reduction in physical sign Seizure freedom as assessed by a daily… compared with standard medical care (very low certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Acyclovir probably leads to higher the proportion of participants with good or excellent rash… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

The rate of resolution of MBO with medical management only in patients receiving OWSC compared with those not receiving it (therapeutic). · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review