Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

369 questions · 382 findings · 20 reviews · Oral and maxillofacial surgery

No studies found 92 · 24.1%GRADE not reported 239 · 62.6%Very low 42 · 11%Low 4 · 1%Moderate 5 · 1.3%High 0 · 0%

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Self-reported joint pain when chewing · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes self-reported joint pain when chewing compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).

1 finding from 1 review

Occlusal splint vs Another occlusal splint with a different mechanism of action

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with another occlusal splint with a different mechanism of action; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Somatisation · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in somatisation compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Muscle pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes muscle pain at rest compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Range of mandibular motion · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in range of mandibular motion compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
    7 studies
    GRADE not reported

Neocone vs Alvogyl

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to higher time to initial pain relief (minutes) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

MRONJ (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
1 finding from 1 review
  • All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
    1 study · 77 participants
    GRADE not reported

Apernyl (acetylsalicylic acid pellet) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Apernyl (acetylsalicylic acid pellet) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Advanced platelet rich fibrin (A-PRF) vs No active treatment (control)

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.

1 finding from 1 review

SaliCept (acemannan hydrogel) vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review