Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 177 findings · 31 reviews

No studies found 18 · 10.2%GRADE not reported 33 · 18.6%Very low 50 · 28.2%Low 57 · 32.2%Moderate 19 · 10.7%High 0 · 0%

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether systemic (oral) betamethasone changes clinical score compared with topical triamcinolone acetonide paste (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs Topical tacrolimus

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes clinical resolution compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Intralesional betamethasone vs intralesional injections of triamcinolone acetonide

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Intralesional betamethasone may leads to higher clinical resolution compared with intralesional triamcinolone acetonide (low certainty).

1 finding from 1 review

Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.025% microspheres showed no clear difference in clinical resolution compared with clobetasol propionate 0.025% ointment; GRADE not reported.

1 finding from 1 review

Dexamethasone mouthwash plus nystatin vs Photodynamic therapy

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs Topical ciclosporin

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide led to lower adverse effects compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Intralesional betamethasone vs intralesional injections of triamcinolone acetonide

Clinical score (14 days) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether intralesional betamethasone changes clinical score (14 days) compared with intralesional triamcinolone acetonide (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs Hyaluronic acid gel

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with hyaluronic acid gel; GRADE not reported.

1 finding from 1 review

Integrated Chinese and Western medicine (incl. oral prednisone) vs Western medicine (incl. oral prednisone)

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Topical triamcinolone acetonide vs Cryotherapy

Pain (mean score, split-mouth) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score, split-mouth) compared with cryotherapy (very low certainty).

1 finding from 1 review

Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.025% microspheres led to higher pain (mean score) compared with clobetasol propionate 0.025% ointment; GRADE not reported.

1 finding from 1 review