Cannabis cigarettes vs placebo
Serious adverse events · people with active UC
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
370 questions · 377 findings · 26 reviews · Gut
No studies found 103 · 27.3%GRADE not reported 11 · 2.9%Very low 99 · 26.3%Low 75 · 19.9%Moderate 67 · 17.8%High 22 · 5.8%
Cannabis cigarettes vs placebo
Withdrawals due to adverse events · people with active UC
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Cannabidiol vs placebo
Clinical response at 10 weeks · people with active UC
Cannabidiol showed no clear difference in clinical response at 10 weeks compared with placebo (low certainty).
1 finding from 1 review
- RR 1.37 [0.59, 3.21]1 study · 60 participantsLow
Cannabidiol vs placebo
CRP (mg/dL) at end of study · people with active UC
1 finding from 1 review
- no estimate extracted1 study · 59 participantsModerate
Cannabidiol vs placebo
IBDQ at week 6 · people with active UC
1 finding from 1 review
- no estimate extracted1 study · 53 participantsModerate
Cannabidiol vs placebo
Adverse events · people with active UC
Cannabidiol probably leads to higher adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.28 [1.05, 1.56]1 study · 60 participantsModerate
Cannabidiol vs placebo
Serious adverse events · people with active UC
Cannabidiol showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 0.15 [0.01, 2.83]1 study · 60 participantsLow
Cannabidiol vs placebo
Withdrawals due to adverse events · people with active UC
Cannabidiol showed no clear difference in withdrawal due to adverse event compared with placebo (low certainty).
1 finding from 1 review
- RR 2.14 [0.83, 5.51]1 study · 60 participantsLow
Cannabis cigarettes vs placebo
Clinical remission · people with active UC
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Cannabis cigarettes vs placebo
Clinical response · people with active UC
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azathioprine vs placebo
Failure to maintain remission · Patients with quiescent ulcerative colitis
Azathioprine may leads to lower failure to maintain remission compared with placebo (low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 0.68 [0.54, 0.86]4 studies · 232 participantsLow
Intervention not reported
Acute pancreatitis · Patients with quiescent ulcerative colitis
It is very uncertain whether the intervention changes acute pancreatitis (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 4.13 [0.48, 35.48]6 studies · 279 participantsVery low
Intervention not reported
Bone marrow suppression · Patients with quiescent ulcerative colitis
It is very uncertain whether the intervention changes bone marrow suppression (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 3.09 [0.64, 14.83]5 studies · 257 participantsVery low
Azathioprine vs placebo
Any adverse events · Patients with quiescent ulcerative colitis
It is very uncertain whether azathioprine changes any adverse events compared with placebo (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 2.51 [0.82, 7.74]4 studies · 232 participantsVery low
Azathioprine vs placebo
Withdrawals due to adverse events · Patients with quiescent ulcerative colitis
It is very uncertain whether azathioprine changes withdrawal due to adverse event compared with placebo (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 7 [0.38, 128.87]3 studies · 152 participantsVery low
Azathioprine vs sulfasalazine
Failure to maintain remission · Patients with quiescent ulcerative colitis
It is very uncertain whether azathioprine changes failure to maintain remission compared with sulfasalazine (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 1.52 [0.66, 3.5]1 study · 25 participantsVery low
6‐Mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)
Failure to maintain remission · Patients with quiescent ulcerative colitis
It is very uncertain whether 6‐Mercaptopurine changes failure to maintain remission compared with 5‐ASA (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 0.53 [0.31, 0.9]1 study · 22 participantsVery low
6‐Mercaptopurine vs methotrexate
Failure to maintain remission · Patients with quiescent ulcerative colitis
It is very uncertain whether 6‐Mercaptopurine changes failure to maintain remission compared with methotrexate (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 0.55 [0.31, 0.95]1 study · 26 participantsVery low
Azathioprine vs cyclosporin of remission
Failure to maintain remission · Patients with quiescent ulcerative colitis
It is very uncertain whether azathioprine (AZA) changes failure to maintain remission compared with cyclosporin of remission (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 0.8 [0.33, 1.92]1 study · 16 participantsVery low
Intervention not reported
Any adverse event · Patients with quiescent ulcerative colitis
It is very uncertain whether the intervention changes any adverse event (very low certainty).
1 finding from 1 review
- Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes onlyRR 2.82 [0.99, 8.01]5 studies · 257 participantsVery low