Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

371 questions · 390 findings · 17 reviews · Orthodontics

No studies found 88 · 22.6%GRADE not reported 203 · 52.1%Very low 38 · 9.7%Low 38 · 9.7%Moderate 20 · 5.1%High 3 · 0.8%

Facemask (with frame internal fixation) vs Frankel III functional appliance

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (with frame internal fixation) showed no clear difference in ANB compared with frankel III functional appliance; GRADE not reported.

1 finding from 1 review

Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

It is very uncertain whether facemask (RME) or modified facemask changes overjet compared with other non-surgical orthodontic treatments (mini maxillary… (very low certainty).

1 finding from 1 review

Bone-anchored intermaxillary traction (BAIMT) vs Removable mandibular retractor (RMR)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Bone-anchored intermaxillary traction (BAIMT) led to higher ANB compared with removable mandibular retractor (RMR); GRADE not reported.

1 finding from 1 review

Hybrid Hyrax (RME) with miniscrews and Class III elastics vs Conventional Hyrax (RME) with miniscrews and Class III elastics

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Hybrid Hyrax (RME) with miniscrews and Class III elastics showed no clear difference in ANB compared with conventional Hyrax (RME) with miniscrews and Class III elastics; GRADE not reported.

1 finding from 1 review

Chin cup (600 g force) vs Chin cup (300 g force)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Chin cup (600 g force) showed no clear difference in ANB compared with chin cup (300 g force); GRADE not reported.

1 finding from 1 review

Facemask vs no intervention

Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask may leads to higher perceived need for surgery in adulthood compared with untreated control (no treatment) (low certainty).

1 finding from 1 review

Malocclusion vs No malocclusion

Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)

Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).

1 finding from 1 review

Malocclusion vs No malocclusion

Poor oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).

1 finding from 1 review

Bonded Minne appliance (slow maxillary expansion) vs Banded Minne appliance (slow maxillary expansion)

Stability of crossbite correction (relapse of canine expansion) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review

Lacebacks with fixed appliances vs Fixed appliances

Size of the lower jaw (arch length) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Lacebacks with fixed appliances showed no clear difference in size of the lower jaw (arch length) compared with fixed appliances only (control); GRADE not reported.

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Schwarz appliance showed no clear difference in size of the lower jaw (mandibular arch length, change) at 9 months compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Nitinol archwire vs Titinol archwire

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether nitinol archwire changes amount of crowding (change) up to 37 weeks compared with titinol archwire (very low certainty).

1 finding from 1 review

Active self-ligating brackets vs Passive self-ligating brackets

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Active self-ligating brackets showed no clear difference in time to alignment (days) compared with passive self-ligating brackets; GRADE not reported.

1 finding from 1 review

Vibrational appliance with fixed appliances vs Fixed appliances

Harms (discomfort, pain intensity, analgesia use) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
  • Orthodontic treatment for crowded teeth in children 2021 · Cochrane All outcomes
    first week
    No clear difference in discomfort/pain intensity or analgesia consumption between vibrational appliance and control (Miles 2012, Miles 2016, Woodhouse 2015; 100 mm VAS). Narrative; no pooled estimate.
    2 studies
    GRADE not reported

Any orthodontic (non-surgical) treatment to correct posterior crossbite or expand the top teeth vs No treatment or another orthodontic treatment

Signs and symptoms of respiratory disease · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

The review found no eligible studies for this question.

1 finding from 1 review

Removable tooth-borne expansion (expansion plate) vs observation

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Removable tooth-borne expansion (expansion plate) leads to higher crossbite correction compared with observation (no treatment) (high certainty).

1 finding from 1 review

Fixed tooth-borne expansion (Hyrax) vs Fixed tooth-tissue-borne expansion (Haas)

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (Hyrax) showed no clear difference in crossbite correction compared with fixed tooth-tissue-borne expansion (Haas) (moderate certainty).

1 finding from 1 review