Findings

What do systematic reviews say?

2,509 questions · 2,666 findings · 288 reviews

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No studies found 743 · 27.9%GRADE not reported 327 · 12.3%Very low 775 · 29.1%Low 484 · 18.2%Moderate 279 · 10.5%High 58 · 2.2%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Neurodevelopmental outcomes · parenterally fed preterm infants with surgical conditions

2 findings from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
GRADE not reported
Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed term and late preterm infants with surgical conditions

It is very uncertain whether fish oil LE changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 1.11 [0.08, 15.28]
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Parenteral nutrition‐associated liver disease/cholestasis · parenterally fed term and late preterm infants with surgical conditions

Fish oil LE showed no clear difference in PNALD/cholestasis (any definition) compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 1.2 [0.38, 3.76]
2 studies · 68 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Culture‐positive sepsis · parenterally fed term and late preterm infants with surgical conditions

It is very uncertain whether fish oil LE changes culture‐positive sepsis compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 1.05 [0.47, 2.34]
2 studies · 51 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Hypertriglyceridaemia · parenterally fed term and late preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 68 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed term and late preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 38 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ALP U/L · parenterally fed term and late preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 38 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Mortality before hospital discharge · parenterally fed term and late preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 68 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Neurodevelopmental outcomes · parenterally fed term and late preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in probing depth (PD) (mm) compared with OFD (open flap debridement) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months
MD 1.29 [1.00, 1.58]
12 studies · 510 participants
Very low

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All studies in all groups reported a survival rate of 100% for the treated teeth (no comparative estimate; not GRADE-rated).
12 studies
GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in radiographic bone defect filling (RBF) (%) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported.

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months
MD 9.99 [6.44, 13.55]
6 studies · 282 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months
MD 4.76 [1.27, 8.25]
6 studies · 162 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 8.10 [5.26, 10.94]
11 studies · 420 participants
Very low

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + guided tissue regeneration… changes change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone (very low certainty).

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 0.42 [-0.02, 0.86]
7 studies · 248 participants
Very low
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months
MD 0.27 [-0.39, 0.93]
5 studies · 164 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months · Split-mouth studies only
MD 0.54 [0.18, 0.89]
3 studies · 134 participants
GRADE not reported

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Long-term skeletal relapse/stability (horizontal movement of A-point) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes long-term skeletal relapse/stability (horizontal movement of A-point) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes
5 years (long-term)
MD 4.80 [0.41, 9.19]
1 study · 16 participants
Very low

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in clinical attachment level (CAL) (mm) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 0.10 [-0.13, 0.32]
2 studies · 75 participants
Very low

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

1 finding from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
No complete pocket closure was reported (outcome addressed across included studies; no usable comparative estimate).
Studies not reported
GRADE not reported

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Speech: resonance (hypernasality) (deterioration/improvement) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes speech: resonance (hypernasality) (deterioration/improvement) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes
17 months (mean)
RR 0.11 [0.01, 1.85]
1 study · 22 participants
Very low

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in clinical attachment level (CAL) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).

3 findings from 1 review

Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
All follow-ups
MD 0.72 [0.43, 1.00]
17 studies · 569 participants
Very low
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
3 to 6 months
MD 0.47 [0.11, 0.84]
11 studies · 272 participants
GRADE not reported
Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes
9 to 12 months · Split-mouth studies only
MD 0.84 [0.62, 1.06]
6 studies · 192 participants
GRADE not reported

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Clinical morbidities (adverse effects) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

1 finding from 1 review

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes
12 months
SoF (Very Low): Clinical morbidities assessed with questionnaires, follow-up 12 months; risk with orthognathic surgery 3/14; risk with maxillary distraction osteogenesis 3/15; relative effect -; 29 participants (1…
1 study · 29 participants
Very low