Total failure: day 28 (PCR‐adjusted) · children under 5 years of age
Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artesunate‐amodiaquine (low certainty).
1 finding from 1 review
Total failure day 28 PCR‐unadjusted · children under 5 years of age
Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐unadjusted compared with artesunate‐amodiaquine (low certainty).
1 finding from 1 review
Early treatment failure · children under 5 years of age
Atovaquone‐proguanil showed no clear difference in early treatment failure compared with artesunate‐amodiaquine (low certainty).
1 finding from 1 review
Haemoglobin (g/dL) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review
Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review
Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age
It is very uncertain whether iron‐fortified wheat flour with or without other micronutrients added changes iron deficiency (as defined by study authors, based on a biomarker… compared with wheat flour (no added iron) with the same other micronutrients added (very low certainty).
1 finding from 1 review
Haemoglobin (g/dL) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review
Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age
Iron‐fortified wheat flour with other micronutrients added probably leads to lower iron deficiency (as defined by study authors, based on a biomarker… compared with unfortified wheat flour (no micronutrients added) (moderate certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder
Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
4 findings from 1 review
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low
Show 1 more finding
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).
1 finding from 1 review
Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).
1 finding from 1 review
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Remission · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether cytidine changes acceptability: total dropouts compared with placebo (very low certainty).
1 finding from 1 review