Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Intervention not reported

Severity of depression dichotomous measures ‐ Tricyclics versus placebo: "very much" or "much" improvement on the Clinical Global Impression scale · patients with depression during opioid agonist treatment for opioid dependence

The intervention probably leads to higher severity of depression dichotomous measures ‐ Tricyclics versus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).

1 finding from 1 review

More frequent (less than eight hours) vs less frequent (eight hours or greater) monitoring of gastric residual volume

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether more frequent (less than eight hours) changes mortality (at the end of compared with less frequent (eight hours or greater) monitoring of gastric… (very low certainty).

1 finding from 1 review