Adverse events · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded).
1 finding from 1 review
Discrimination of caries vs health (random forest ROC-AUC) · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
Microbiome-based random forest classifiers could not reliably discriminate caries from health across the combined cohort (best AUC approximately 0.75 in a disease-only KO subset; ungraded).
1 finding from 1 review
Retention of sealant (complete or partial retention) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
Chadwick 2005: one or more sealants fully/partially retained in 69 (31.2%) children at 12-30 months; Joshi 2019: at 12 months 75 (43.6%) teeth completely retained, 58 (33.7%) partially retained, 39 (22.7%) completely…
2 studies
GRADE not reported
Retention of sealant (complete or partial retention) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
It is very uncertain whether autopolymerised sealant changes retention of sealant (complete or partial retention) compared with light polymerised sealant (very low certainty).
1 finding from 1 review
Retention of sealant (complete or partial retention) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
1 finding from 1 review
At 12 months, sealants on 96 (70.1%) surfaces completely retained, 25 (18.3%) partially retained, 16 (11.6%) completely lost; at 24 months, 58 (45.3%) completely retained, 29 (22.7%) partially retained, 41 (32%)…
1 study
GRADE not reported
Adverse events · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of non-cavitated enamel caries · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)
No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).
1 finding from 1 review
Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
5 studies · 420 participants
GRADE not reported
Development of >=1 new carious lesion (caries incidence) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
N/A - insufficient quantitative information available; 200 (2 studies). Comments: Due to the methods of data collection, analysis and reporting we were unable to provide any quantitative estimates. Fei 2011 narrative:…
2 studies · 200 participants
Very low
Development of >=1 new carious lesion (caries incidence) · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)
1 finding from 1 review
N/A - insufficient quantitative information available; 69 (2 studies). Comments: Due to the different sealant materials, data reporting (split-mouth studies reported as parallel-group) and the very low number of tooth…
2 studies · 69 participants
Low
KEGG pathway associations · Participants in oral 16S rRNA caries microbiome studies
Phosphonate and phosphinate metabolism and glyoxylate and dicarboxylate metabolism had the lowest reported adjusted P values (0.04); no pooled effect estimate was reported.
1 finding from 1 review
Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty).
2 findings from 1 review
Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
It is very uncertain whether autopolymerised sealant changes development of >=1 new carious lesion (caries incidence) compared with light polymerised sealant (very low certainty).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
The review found no eligible studies for this question.
1 finding from 1 review
Beta diversity and community composition · Participants in oral 16S rRNA caries microbiome studies
Beta-diversity matrices showed statistically significant ADONIS results, while clustering by study and 16S region was also observed; no pooled effect estimate was reported.
1 finding from 1 review
Intervention not reported
Enamel acid resistance / initiation of new enamel caries lesions (in vivo, narrative)
1 finding from 1 review
External disease-state discrimination · Oral microbiome samples from four selected case-control studies
The KEGG Orthology classifier had an approximate AUC of 0.75 in the disease-only study test set.
1 finding from 1 review
AUC 0.75
4 studies
GRADE not reported
Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
1 finding from 1 review
Effect estimate not calculable. All sealants were completely or partially retained; 40 (1 RCT). Flowable composite: 39/40 completely retained (1 partially lost) at 6 months; resin-based: 33 completely and 7 partially…
1 study · 40 participants
Low