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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Theory-based oral health education/promotion interventions (HBM, TPB, SCT, HAPA, TTM, PMT, SOC, PRECEDE-PROCEED, MI) vs Control (waitlist, routine/standard oral health education, or minimal intervention)

Oral health-related quality of life · school‐age children and adolescents

Theory-based interventions significantly improved oral health-related quality of life (SMD 7.38; low certainty), with very high heterogeneity.

1 finding from 1 review

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Absence of secondary caries · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

Ion-releasing and composite restorations show no significant difference in absence of secondary caries in children (high certainty).

1 finding from 1 review

Biodentine vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

Biodentine and calcium hydroxide did not differ significantly in clinical and radiographic success (OR 3.14, 95% CI 0.91 to 10.86; ungraded subgroup analysis).

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective amalgam restoration with loss of dental hard substance adjacent to the restoration, surveyed dentists most often preferred replacement over repair (pooled RR 4.70; p < 0.001); ungraded.

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Amalgam: Preference for replacement over repair - Scenario 6: corrosion · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective amalgam restoration with corrosion, surveyed dentists most often preferred replacement over repair (pooled RR 1.59; p < 0.001); ungraded.

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

Subgroup (HDI: Very high): pooled preference was replacement over repair for a defective amalgam restoration with marginal discoloration (RR 6.48); significant HDI variation, p = 0.01.

5 findings from 1 review
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Electronic cigarette use vs Non-smokers

IL-1β level · People who use electronic cigarettes

The review reports no significant e-cigarette effect on salivary IL-1β.

3 findings from 1 review

Higher national income (GNI per capita) vs Lower national income (GNI categories: middle <=$15,000 / high $15,001-25,000 / very high >$25,000)

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)

Mean DMFT in 12-year-olds rises as national income falls: 0.90 (very high income), 2.38 (high income), 3.30 (middle income) (Figure 2); not GRADE-rated.

3 findings from 1 review

Genetically predicted periodontitis vs Without periodontitis (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037).

1 finding from 1 review