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What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

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No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Summary of findings table ‐ Collagen vs standard diet or placebo

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · adults with pressure ulcers

It is very uncertain whether summary of findings table ‐ Collagen changes side effects: at least one adverse event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Health‐related quality of life ‐ not reported · inpatients who are mildly or seriously malnourished or at risk of being malnourished, elderly patients at risk of developing pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review