Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,549 questions · 1,604 findings · 181 reviews

No studies found 258 · 16.1%GRADE not reported 69 · 4.3%Very low 337 · 21%Low 406 · 25.3%Moderate 410 · 25.6%High 124 · 7.7%

Intervention not reported

Number of participants improved after 12 weeks (excluding those who did not complete the study) NIS score (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy

It is very uncertain whether the intervention changes number of participants improved after 12 weeks (excluding those who… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants improved after 12 weeks (including those who did not complete the study) NIS (range 0 to 280) · people with chronic inflammatory demyelinating polyradiculoneuropathy

It is very uncertain whether the intervention changes number of participants improved after 12 weeks (including those who… (very low certainty).

1 finding from 1 review

Monthly pulsed high‐dose dexamethasone vs prednisolone

≥ 1 point improvement on INCAT disability score at 12 months · patients with chronic inflammatory demyelinating polyradiculoneuropathy

Monthly pulsed high‐dose dexamethasone may leads to higher ≥ 1 point improvement on INCAT disability score at 12 months compared with oral prednisolone (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants who completed the study and did not restart IVIg therapy after IVIg withdrawal · people with CIDP

Interferon beta‐1a showed no clear difference in participants who completed the study and did not restart IVIg… compared with placebo (moderate certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ short‐term · Adults with plantar heel pain¹

Local steroid injection showed no clear difference in heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ short‐term compared with placebo or no treatment control (low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ medium‐term · Adults with plantar heel pain¹

Local steroid injection showed no clear difference in heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ medium‐term compared with placebo or no treatment control (low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Function: medium‐term FFI (0 to 100: higher scores = worse function) FHSQ (0 to 100: higher scores = better function · Adults with plantar heel pain¹

It is very uncertain whether local steroid injection changes function: medium‐term FFI (0 to 100: higher scores = worse function)… compared with placebo or no treatment control (very low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Treatment failure (Heel pain persists at 8 weeks; subsequent treatment at 12 weeks; no pain relief at 6 months) · Adults with plantar heel pain¹

It is very uncertain whether local steroid injection changes treatment failure (Heel pain persists at 8 weeks; subsequent… compared with placebo or no treatment control (very low certainty).

1 finding from 1 review