Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse events: Oral cavity disorders (includes oral dryness and mucositis)‐ · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Oral cavity disorders (includes oral dryness and… compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Clinical pregnancy per woman ‐ oral route · women trying to conceive by intrauterine insemination

It is very uncertain whether progesterone changes clinical pregnancy per woman ‐ oral route compared with no treatment or placebo (route of progesterone administration) (very low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

IgE‐mediated food allergy (oral food challenge) by 1 to 3 years · infants

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ cohort studies orally · children 9 months to 15 years old

It is very uncertain whether the intervention changes temperature ‐ cohort studies orally (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured after 4 weeks · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…

It is very uncertain whether systemic antibiotics changes resolution of ear discharge ‐ measured after 4 weeks (6 weeks) (Oral… compared with no treatment or placebo on top of topical antibiotics (very low certainty).

1 finding from 1 review