Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both), only first episode in number of participants · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with at least 1 bleeding episode · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one bleeding episode compared with placebo (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with severe or life‐threatening bleeding · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one severe or life‐threatening… compared with placebo (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Proportion of patients receiving platelets · People with chronic bone marrow failure

Thrombopoietin mimetic probably leads to lower proportion of participants receiving a platelet transfusion compared with placebo (moderate certainty).

1 finding from 1 review

Minimal invasive discectomy vs micro/discectomy

Side effects ‐ surgical site and other infections > 6 months' · participants with lumbar disc herniation

Minimal invasive discectomy probably leads to lower side effects ‐ surgical site and other infections > 6 months' compared with micro/discectomy (moderate certainty).

1 finding from 1 review

Minimal invasive discectomy vs micro/discectomy

Side effects ‐ re‐hospitalisation due to recurrent disc herniation ≥ 6 months' · participants with lumbar disc herniation

Minimal invasive discectomy may leads to higher side effects ‐ re‐hospitalisation due to recurrent disc herniation ≥… compared with micro/discectomy (low certainty).

1 finding from 1 review

Minimal invasive discectomy vs micro/discectomy

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants with lumbar disc herniation
2 findings from 1 review