Annualized joint Bleeding Rate (AjBR) · children or adults with hemophilia A
Prophylaxis with standard therapeutic factor concentrate showed no clear difference in AJBR compared with pegylated liposome FVIII formulation (low certainty).
1 finding from 1 review
ABR · children or adults with hemophilia A
Prophylaxis with standard therapeutic factor concentrate showed no clear difference in ABR compared with pegylated liposome FVIII formulation (low certainty).
1 finding from 1 review
Any reported adverse effects · children or adults with hemophilia A
1 finding from 1 review
Number of joint bleeding episodes or joint bleeding frequency · participants with haemophilia
Prophylaxis regimen showed no clear difference in number of joint bleeding episodes or joint bleeding frequency compared with on‐demand treatment (low certainty).
1 finding from 1 review
Number of total bleeds per year or bleeding frequency · participants with haemophilia
Prophylaxis regimen showed no clear difference in number of total bleeds per year or bleeding frequency compared with on‐demand treatment (low certainty).
1 finding from 1 review
Any reported adverse events · participants with haemophilia
Prophylaxis regimen probably leads to higher any reported adverse events compared with on‐demand treatment (moderate certainty).
1 finding from 1 review
FEV1 % predicted · children with cystic fibrosis
1 finding from 1 review
Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis
Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis
Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Need for additional antibiotic therapy · children with cystic fibrosis
Summary of findings ‐ Prophylactic showed no clear difference in number of people needing additional antibiotics compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Weight (z score) · children with cystic fibrosis
1 finding from 1 review
Acquisition of multiply‐resistant S aureus · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events of treatment · children with cystic fibrosis
1 finding from 1 review
Pulmonary exacerbations · adults and children with cystic fibrosis
1 finding from 1 review
Diarrhoea · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes adverse events: diarrhoea compared with placebo (very low certainty).
1 finding from 1 review
FEV1 % predicted · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes FEV1 % predicted compared with placebo (very low certainty).
1 finding from 1 review
FVC · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes FVC % predicted compared with placebo (very low certainty).
1 finding from 1 review
Z score BMI · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes growth and nutrition: BMI SD score compared with placebo (very low certainty).
1 finding from 1 review
Biochemical markers of essential fatty acid status: EPA and DHA % content of neutrophil membrane · adults and children with cystic fibrosis
1 finding from 1 review
Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions
Long‐term red cell transfusion probably leads to lower clinical stroke compared with no transfusion (moderate certainty).
1 finding from 1 review