Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,438 questions · 1,463 findings · 125 reviews · Anaesthesia

No studies found 197 · 13.5%GRADE not reported 203 · 13.9%Very low 307 · 21%Low 441 · 30.1%Moderate 245 · 16.7%High 70 · 4.8%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ low dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

Clonidine vs midazolam

Haemodynamic or respiratory changes requiring intervention · patients with postoperative pain

Clonidine probably leads to lower haemodynamic or respiratory changes requiring intervention compared with midazolam (moderate certainty).

1 finding from 1 review

Clonidine vs fentanyl

Additional analgesia required (escape analgesia) · patients with postoperative pain

Clonidine showed no clear difference in number requiring additional analgesia at any time postoperatively compared with fentanyl (moderate certainty).

1 finding from 1 review

Intervention not reported

Mean temperature difference (60 minutes after warming started): not reported · adults with postoperative hypothermia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Rate of rewarming: not reported · adults with postoperative hypothermia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Major cardiovascular complications: not reported · adults with postoperative hypothermia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pain (number of patients) Thermal vs warmed cotton blanket · adults with postoperative hypothermia

The intervention showed no clear difference in pain (number of patients) Thermal vs warmed cotton blanket (moderate certainty).

1 finding from 1 review

Intervention not reported

Shivering (number of patients) Thermal vs warmed cotton blanket · adults with postoperative hypothermia

The intervention showed no clear difference in shivering (number of patients) Thermal vs warmed cotton blanket (moderate certainty).

1 finding from 1 review