Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,922 questions · 3,118 findings · 513 reviews

No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

NSAIDs vs placebo

Change in pain intensity from baseline on VAS (0 to 100) short‐term · people with low back pain with sciatica

It is very uncertain whether NSAIDs changes change in pain intensity from baseline on VAS (0 to 100) short‐term compared with placebo (very low certainty).

1 finding from 1 review

Topical treatments (lactoperoxidase oral rinse / Biotene) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether topical treatments (lactoperoxidase oral rinse / Biotene) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Dietary supplements (hypericum perforatum / St John's Wort) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · hypericum perforatum
    Hypericum perforatum extract (Sardella 2008, the only low-risk-of-bias study) contributes to the dietary supplements short-term symptom-relief comparison (insufficient/contradictory); no separate estimate reported.
    1 study · 43 participants
    GRADE not reported

Paroxetine vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Dose/intensity and frequency of pain relief needed (analgesic/rescue medication use) · Adolescents/teenagers undergoing orthodontic treatment
1 finding from 1 review

Dietary supplements (alpha lipoic acid +/- vitamins) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- vitamins) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Anticonvulsants (gabapentin + alpha lipoic acid) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · gabapentin with adjunctive ALA
    SoF2 subgroup. Gabapentin + adjunctive ALA vs placebo forms one of two subgroups of the anticonvulsant symptom-relief estimate (RR 4.00, 2.09 to 7.67); no between-subgroup difference vs gabapentin alone; 100…
    1 study · 40 participants
    Very low

Additional radon in carbon dioxide baths vs carbon dioxide baths only

Improvement More than 1 category change in pain intensity on 4‐point scale (no pain/sporadic/daily/continuous) · patients with rheumatoid arthritis

Additional radon in carbon dioxide baths showed no clear difference in improvement More than 1 category change in pain intensity on 4‐point… compared with carbon dioxide baths only (low certainty).

2 findings from 1 review

Reduced number of antenatal care visits/goal‐oriented vs standard antenatal care visits

Hypertensive disorders of pregnancy (including pre‐eclampsia) · Pregnant women at low risk of complications

Reduced number of antenatal care visits/goal‐oriented showed no clear difference in hypertensive disorders of pregnancy (including pre‐eclampsia) compared with standard antenatal care visits (low certainty).

1 finding from 1 review

Reduced number of antenatal care visits/goal‐oriented vs standard antenatal care visits

Admission to neonatal intensive care unit · Pregnant women at low risk of complications

Reduced number of antenatal care visits/goal‐oriented showed no clear difference in neonatal intensive care unit admission compared with standard antenatal care visits (moderate certainty).

1 finding from 1 review

Low‐back pain: any exercises + usual prenatal care vs usual prenatal care

Pain intensity measured by a number of different measurements; lower score = better. · pregnant women with back pain

Low‐back pain: any exercises + usual prenatal care showed no clear difference in pain intensity measured by a number of different measurements; lower… compared with usual prenatal care (low certainty).

1 finding from 1 review

All routine Doppler ultrasound vs no Doppler ultrasound

Admission to neonatal special care unit or intensive care unit · Pregnant women in unselected or low‐risk populations.

All routine Doppler ultrasound showed no clear difference in neonatal admission to special care baby unit/neonatal intensive care… compared with no Doppler ultrasound (moderate certainty).

1 finding from 1 review

Massage vs inactive control

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with LBP
1 finding from 1 review

Massage vs active control

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with LBP
1 finding from 1 review