Intervention not reported
TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin) Comparator…
1 finding from 1 review
no estimate extracted
3 participants
Low
Intervention not reported
TXA given intravenously and orally at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
3 participants
Low
Intervention not reported
TXA given intravenously and orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
no estimate extracted
3 participants
Low
Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema
Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).
1 finding from 1 review
Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema
Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).
1 finding from 1 review
Time to resolution of primary hemorrhage · people with traumatic hyphema
1 finding from 1 review
Risk of secondary hemorrhage; oral corticosteroids · people with traumatic hyphema
Systemic or topical corticosteroids may leads to lower risk of secondary hemorrhage; oral corticosteroids compared with placebo or control treatment (low certainty).
1 finding from 1 review
Intervention not reported
Face‐to‐face behavioral intervention vs minimal or no support (Measured 3 to 6 months with CO‐validated prolonged and continuous abstinence, and self‐reported abstinence) · people who use waterpipe
The intervention may leads to higher face‐to‐face behavioral intervention vs minimal or no support… (low certainty).
1 finding from 1 review
RR 2.64 [1.66, 4.2]
851 participants
Low
Intervention not reported
Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe
The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).
1 finding from 1 review
Intervention not reported
Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe
It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).
1 finding from 1 review
RR 0.77 [0.42, 1.41]
121 participants
Very low
Intervention not reported
Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe
It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).
1 finding from 1 review
RR 1.94 [0.94, 4]
86 participants
Very low
Kujala patellofemoral disorders score Scale from: 0 to 100 (higher scores = better function) · people with lateral patellar dislocation
It is very uncertain whether surgical changes knee and physical functiona Measured using the Kujala patellofemoral… compared with non‐surgical treatment (very low certainty).
1 finding from 1 review
BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and osteoporosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass
Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).
1 finding from 1 review
BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and low bone mass
Summary of findings – denosumab showed no clear difference in BMD Z score (total hip/femoral neck) compared with placebo (low certainty).
1 finding from 1 review
BMD Z score (total hip/femoral neck) · women with low bone mass and β‐thalassaemia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
BMD Z score (total hip/femoral neck) · people with β‐thalassaemia and osteoporosis
It is very uncertain whether the intervention changes BMD Z score (total hip/femoral neck) (very low certainty).
1 finding from 1 review
Resolution or reduction in severity of any other dental complication: oral infections (measured by reduction in or resolution of lesions such as periapical cysts, abscesses, or space infections) · people with thalassaemia (any age)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Smoking cessation ‐ oral spray versus gum · people who smoke
It is very uncertain whether the intervention changes smoking cessation ‐ oral spray versus gum (very low certainty).
1 finding from 1 review
Intervention not reported
Smoking cessation ‐ oral spray versus inhaler · people who smoke
It is very uncertain whether the intervention changes smoking cessation ‐ oral spray versus inhaler (very low certainty).
1 finding from 1 review