Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,388 questions · 1,444 findings · 167 reviews

No studies found 336 · 23.3%GRADE not reported 67 · 4.6%Very low 419 · 29%Low 395 · 27.4%Moderate 188 · 13%High 39 · 2.7%

GnRHa treatment vs placebo or no pretreatment

Blood transfusion · women with uterine fibroids

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Overall postoperative morbidity · women with uterine fibroids

GnRHa treatment showed no clear difference in postoperative morbidity compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

SPRM vs placebo

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg compared with placebo (low certainty).

1 finding from 1 review

SPRM vs placebo

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: Reduction in menstrual bleeding (PBAC < 75)… compared with placebo (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Unplanned surgical intervention · incomplete miscarriage

Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Women's views/acceptability of method · incomplete miscarriage

Misoprostol showed no clear difference in women's views/acceptability of method compared with surgery (moderate certainty).

1 finding from 1 review