Phlebotonics vs placebo?
Oedema in the lower legs (ankle circumference, mm) · patients with venous insufficiency
1 finding from 1 review
- no estimate extracted15 studies · 2010 participantsModerate
Findings
What do systematic reviews say?
4,760 questions · 8,065 findings · 1,036 reviews
No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%
Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.
Antibiotic prophylaxis vs placebo
DSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
Antibiotic prophylaxis showed no clear difference in DSSI ‐ low infection risk environment compared with placebo (moderate certainty).
1 finding from 1 review
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or… 2020 · Cochrane Headline outcomes onlyRR 0.67 [0.11, 4.13]3 studies · 1488 participantsModerate
Antibiotic prophylaxis vs placebo
All wound infections (SSSI + DSSI) ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) ‐ low infection risk environment compared with placebo (very low certainty).
2 findings from 1 review
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or… 2020 · Cochrane Headline outcomes onlyRR 0.63 [0.28, 1.41]4 studies · 1302 participantsVery low
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or… 2020 · Cochrane Headline outcomes onlyRR 0.71 [0.44, 1.14]9 studies · 3100 participantsModerate
Antibiotic prophylaxis vs placebo
SSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
Antibiotic prophylaxis showed no clear difference in SSSI ‐ low infection risk environment compared with placebo (moderate certainty).
1 finding from 1 review
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or… 2020 · Cochrane Headline outcomes onlyRR 0.71 [0.44, 1.17]9 studies · 3100 participantsModerate
Radiotherapy vs control
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · people with neovascular AMD
1 finding from 1 review
- Radiotherapy for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedLow
Radiotherapy combined with anti‐VEGF vs anti‐VEGF alone
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · people with neovascular AMD
Radiotherapy combined with anti‐VEGF showed no clear difference in change in best corrected visual acuity (logMAR units) Measured using… compared with anti‐VEGF alone (low certainty).
1 finding from 1 review
- Radiotherapy for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes onlymean difference 0.1Studies not reportedLow
Behavioural therapy plus treatment as usual vs treatment
Reduction in physical signs (symptom severity) Measured by Clinical Global Impression scale (lower is better) · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 90 participantsVery low
Cognitive behavioural therapy as vs standard‐of‐care therapy
Reduction in physical signs Decrease in seizure frequency End of treatment · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 61 participantsLow
Cognitive behavioural therapy as vs standard‐of‐care therapy
Level of functioning · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 74 participantsVery low
Specialised cognitive behavioural therapy‐based physiotherapy vs treatment
Level of functioning · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 54 participantsVery low
Brief psychotherapeutic intervention vs usual care
Reduction in physical signs As assessed by SDQ‐20 (lower is better) · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
It is very uncertain whether brief psychotherapeutic intervention changes reduction in physical signs As assessed by SDQ‐20 (lower is better) compared with standard care (very low certainty).
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyRR 0.12 [0.01, 2]1 study · 19 participantsVery low
Brief psychotherapeutic intervention vs usual care
Quality of life As assessed by SF‐36 (lower is better) · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 16 participantsVery low
Cognitive behavioural therapy plus adjunctive physical activity vs cognitive behavioural therapy
Reduction in physical signs (overall physical impact) As measured by PMDRS, total score (lower is better) · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 21 participantsVery low
Psychotherapy preceded by motivational interviewing vs psychotherapy alone
Quality of life As measured by QOLIE10 (lower is better) · people with conversion disorder according to DSM‐IV or ICD‐10 criteria
1 finding from 1 review
- Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 47 participantsVery low
Intravitreal dexamethasone implant 0.7 mg vs antiVEGF
Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher use of IOP‐lowering medications ‐ 24 months compared with intravitreal antiVEGF (moderate certainty).
1 finding from 1 review
- RR 4.76 [2.84, 7.99]Studies not reportedModerate
Intravitreal fluocinolone acetonide implant 0.19 mg vs sham
Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes
Intravitreal fluocinolone acetonide implant 0.19 mg probably leads to higher use of IOP‐lowering medications ‐ 24 months compared with sham (moderate certainty).
1 finding from 1 review
- RR 2.72 [1.87, 3.98]1 study · 558 participantsModerate
Intravitreal triamcinolone acetonide injection 4 mg vs sham
Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes
It is very uncertain whether intravitreal triamcinolone acetonide injection 4 mg changes use of IOP‐lowering medications ‐ 24 months compared with sham (very low certainty).
1 finding from 1 review
- RR 21.6 [1.32, 354.7]Studies not reportedVery low
Intravitreal triamcinolone acetonide injection 4 mg vs macular laser
Use of IOP‐lowering medications · macular edema in diabetes
Intravitreal triamcinolone acetonide injection 4 mg probably leads to higher use of IOP‐lowering medications ‐ 9 to 24 months compared with macular laser (moderate certainty).
1 finding from 1 review
- RR 3.92 [2.59, 5.96]Studies not reportedModerate
Intravitreal triamcinolone acetonide injection 4 mg vs antiVEGF
Use of IOP‐lowering medications · macular edema in diabetes
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Intravitreal dexamethasone implant 0.7 mg vs sham
Use of IOP‐lowering medications · macular edema in diabetes
Intravitreal dexamethasone implant 0.7 mg probably leads to higher use of IOP‐lowering medications ‐ 36 months compared with sham (moderate certainty).
1 finding from 1 review
- RR 4.54 [3.19, 6.46]1 study · 697 participantsModerate