Cochrane · systematic review · CD003229
Phlebotonics for venous insufficiency
Martinez-Zapata, MJ, Vernooij, RWM, Simancas-Racines, D, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 4 · 80%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsDo phlebotonics improve signs and symptoms of venous insufficiency when compared with placebo?
Population: patients with venous insufficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oedema in the lower legs (dichotomous variable) Do phlebotonics improve signs and symptoms of venous insufficiency when vs placebo? | RR 0.7 [0.63, 0.78] | 13 studies · 1245 participants | Moderate Downgraded: risk of bias |
Oedema in the lower legs (ankle circumference, mm) Do phlebotonics improve signs and symptoms of venous insufficiency when vs placebo? | no estimate extracted | 15 studies · 2010 participants | Moderate Downgraded: risk of bias |
Quality of life (CIVIQ and other questionnaires) Do phlebotonics improve signs and symptoms of venous insufficiency when vs placebo? | no estimate extracted | 5 studies · 1639 participants | Moderate Downgraded: risk of bias, imprecision |
Ulcer healing (dichotomous variable) Do phlebotonics improve signs and symptoms of venous insufficiency when vs placebo? | RR 0.94 [0.79, 1.13] | 6 studies · 461 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Do phlebotonics improve signs and symptoms of venous insufficiency when vs placebo? | RR 1.14 [1.02, 1.27] | 37 studies · 5789 participants | Moderate Downgraded: risk of bias |