Search review questions

Pneumococcal colonization ‐ By 6‐7 months of age · Pregnant women undergoing vaccination to prevent infant infection

Perinatal death and or severe morbidity (neonatal intensive care unit admission, neonatal encephalopathy) · Pregnant women who had reached the gestational age of fetal viability

Caesarean section · Pregnant women who had reached the gestational age of fetal viability

Perinatal death · Pregnant women who had reached the gestational age of fetal viability

Maternal anxiety · Pregnant women who had reached the gestational age of fetal viability

Maternal‐fetal attachment · Pregnant women who had reached the gestational age of fetal viability

Antenatal hospital admission rate per cluster (mean) · Pregnant women who had reached the gestational age of fetal viability

Low birthweight (< 2500 g or < 10th centile) · Pregnant women who had reached the gestational age of fetal viability

Perinatal death · Women with a multiple pregnancy for improving maternal and infant outcomes

Caesarean birth · Women with a multiple pregnancy for improving maternal and infant outcomes

Postnatal depression (6 months' postpartum). EPDS score 13 or more. · Women with a multiple pregnancy for improving maternal and infant outcomes

Breastfeeding 6 months' postpartum · Women with a multiple pregnancy for improving maternal and infant outcomes

Small‐for‐gestational age · Women with a multiple pregnancy for improving maternal and infant outcomes

Very preterm birth (defined as birth less than 34 weeks' gestation) · Women with a multiple pregnancy for improving maternal and infant outcomes

Rate of toxoplasmosis seroconversion in pregnant women · women of reproductive age, irrespective of their pregnant status

Pregnant women behavior with respect to the avoidance of risk factors for toxoplasmosis infection during pregnancy (no consumption of uncooked meat of any type) · women of reproductive age, irrespective of their pregnant status

Pregnant women behavior with respect to the avoidance of risk factors for toxoplasmosis during pregnancy (hand washing after contact with transmission factor and before meals) · women of reproductive age, irrespective of their pregnant status

Rate of congenital toxoplasmosis defined by persistence of IgG antibodies beyond 11 months · women of reproductive age, irrespective of their pregnant status

Pregnant women knowledge of risk factors for acquiring toxoplasmosis infection as objectively measured through specific questionnaire · women of reproductive age, irrespective of their pregnant status

Pregnant women awareness of the importance of avoiding toxoplasmosis infection during pregnancy as objectively measured through specific questionnaire · women of reproductive age, irrespective of their pregnant status

Preterm birth less than 37 weeks · pregnant women presenting for routine prenatal care

Preterm low birthweight (below or equal 2500 g) · pregnant women presenting for routine prenatal care

Preterm very low birthweight (below or equal 1500 g) · pregnant women presenting for routine prenatal care

Maternal death or serious maternal morbidity · women with a twin pregnancy

Perinatal or neonatal death or serious neonatal morbidity · women with a twin pregnancy

Disability in childhood · women with a twin pregnancy

Perinatal or neonatal death · women with a twin pregnancy

Serious neonatal morbidity · women with a twin pregnancy

Longer‐term maternal outcomes: failure to breastfeed · women with a twin pregnancy

Longer‐term maternal outcomes: postnatal depression, as defined by trial authors (EPDS > 12) · women with a twin pregnancy

Birthweight (g) · Pregnant women recruited before 20 weeks' gestation

Preterm birth · Pregnant women recruited before 20 weeks' gestation

Low birthweight · Pregnant women recruited before 20 weeks' gestation

Perinatal mortality rate · Pregnant women recruited before 20 weeks' gestation

Sudden infant death syndrome · Pregnant women recruited before 20 weeks' gestation

Gestational diabetes · Pregnant women recruited before 20 weeks' gestation

Detection of fetal abnormality before 24 weeks' gestation · Pregnant women at less than 24 weeks' gestation undergoing fetal assessment by ultrasound

Detection of multiple pregnancy by 24 to 26 weeks' gestation (number NOT detected) · Pregnant women at less than 24 weeks' gestation undergoing fetal assessment by ultrasound

Induction of labour for 'post‐term' pregnancy · Pregnant women at less than 24 weeks' gestation undergoing fetal assessment by ultrasound

Perinatal death (all babies) · Pregnant women at less than 24 weeks' gestation undergoing fetal assessment by ultrasound

Preterm birth (a) Birth prior to 37 weeks · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Preterm birth (b) Birth prior to 34 weeks · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Low birthweight (< 2500 g) · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Excessive weight gain · pregnant women

Mean GWG (kg) · pregnant women

Low weight gain · pregnant women

Preterm birth · pregnant women

Pre‐eclampsia · pregnant women

Caesarean delivery · pregnant women

Macrosomia Infant birthweight > 4000 g · pregnant women