Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,793 questions · 1,866 findings · 339 reviews

No studies found 245 · 13.1%GRADE not reported 142 · 7.6%Very low 612 · 32.8%Low 513 · 27.5%Moderate 305 · 16.3%High 49 · 2.6%

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG vs antipsychotics

No clinically important response to treatment ‐ short term · patients with schizophrenia

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG may leads to lower SENSITIVITY ‐ Global/mental state: No clinically important response… compared with ANY ANTIPSYCHOTIC DRUG (low certainty).

1 finding from 1 review

CLOZAPINE vs Typical antipsychotics

Relapse · patients with schizophrenia

CLOZAPINE probably leads to lower relapse ‐ short term compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).

2 findings from 1 review

CLOZAPINE vs Typical antipsychotics

Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia

CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

2 findings from 1 review

Intervention not reported

Mental state: 1a. Overall no clinically important improvement (BPRS) ‐ short term 25‐30% change BPRS1,2 ( · people with schizophrenia

The intervention showed no clear difference in mental state: 1a. Overall no clinically important improvement (BPRS)… (low certainty).

1 finding from 1 review

High MCT formula vs low MCT formula

Weight gain · promoting short‐term growth of preterm infants
2 findings from 1 review

Endovenous laser ablation (EVLA) vs conventional surgery

Recanalisation or persistence of reflux at 6 weeks · people requiring intervention for short saphenous vein varices

Endovenous laser ablation probably leads to lower recanalisation or persistence of reflux at 6 weeks compared with conventional surgery (moderate certainty).

1 finding from 1 review