What do systematic reviews say?

Summary of findings ‐ triple therapy: VX‐440‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Summary of findings ‐ triple therapy: VX‐152‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Low

Summary of findings ‐ triple therapy: VX‐152‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Low

Summary of findings table ‐ DMT vs waiting list control

• Dance movement therapy for dementia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Summary of findings table ‐ DMT vs exercise

• Dance movement therapy for dementia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 136 participants
  Low

Mobile phone interventions vs usual care

Summary of findings table ‐ Mobile phone‐based interventions showed no clear difference in pregnancy compared with standard of care (moderate certainty).

• Mobile phone‐based interventions for improving contraception use 2023 · Cochrane Headline outcomes only
  OR 0.82 [0.48, 1.38]
  8 studies · 2947 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes pregnancy rate (clinical or positive urine pregnancy test) (very low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.08 [0.89, 1.3]
  3 studies · 262 participants
  Very low

Intervention not reported

The intervention showed no clear difference in time to pregnancy (low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  HR 0.86 [0.53, 1.38]
  1 study · 140 participants
  Low

Intervention not reported

The intervention showed no clear difference in clinical pregnancy rate (low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.09 [0.51, 2.31]
  1 study · 148 participants
  Low

Intervention not reported

The intervention probably leads to higher pregnancy rate(clinical pregnancy or urine pregnancy test) (moderate certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.28 [1.09, 1.5]
  4 studies · 2202 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes time to pregnancy (very low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  OR 1.77 [0.1, 3.2]
  2 studies · 2 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes clinical pregnancy rate (very low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.13 [0.31, 4.07]
  1 study · 17 participants
  Very low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes delayed antibiotic prescriptions compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.32 [0.74, 2.35]
  1 study · 53 participants
  Very low

Paracetamol vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

The review found no eligible studies for this question.

• Different intensities of glycaemic control for women with gestational diabetes mellitus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hydroxyurea vs placebo

• Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 142 participants
  Very low

Angiotensin‐converting enzyme inhibitors vs placebo

• Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Very low

Angiotensin‐converting enzyme inhibitors vs vitamin C

• Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 170 participants
  Very low

Intervention not reported

The intervention may leads to higher breast cancer stage at the time of presentation: defined as the… (low certainty).

• Training health workers in clinical breast examination for early detection of breast cancer in low‐ and middle‐income… 2023 · Cochrane Headline outcomes only
  RR 1.44 [1.01, 2.06]
  3 studies · 593 participants
  Low