Findings

What do systematic reviews say?

1,281 questions · 1,307 findings · 212 reviews

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No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Probenecid vs allopurinol

Withdrawals due to adverse events ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Total adverse events ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.27 [0.9, 1.79]
2 studies · 101 participants
Moderate

Probenecid vs allopurinol

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.25 [0.28, 5.62]
2 studies · 91 participants
Low

Benzbromarone vs allopurinol

Total adverse events · people with chronic gout

Benzbromarone showed no clear difference in total adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 3 [0.64, 14.16]
1 study · 55 participants
Low

Benzbromarone vs allopurinol

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs probenecid

Acute gout attacks · people with chronic gout

Benzbromarone showed no clear difference in acute gout attacks compared with probenecid (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.73 [0.09, 5.83]
2 studies · 129 participants
Low

Benzbromarone vs probenecid

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) · people with chronic gout

Benzbromarone probably leads to higher serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) compared with probenecid (moderate certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.43 [1.02, 2]
1 study · 62 participants
Moderate

Endpoint International Index of Erectile Function (IIEF) total scores (The IIEF is a self‐report measure with 15 questions examining erectile function, orgasmic function, sexual desire, and intercourse satisfaction. Maximum possible score 75) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ question 3: ability to achieve erection (Maximum score 5) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 231 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ intercourse satisfaction (questions 6, 7, 8) (Maximum score 15) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Moderate

Sildenafil vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Sildenafil probably leads to lower clinical Global Impression ‐Sexual Function not "much/very much… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.44 [0.33, 0.58]
2 studies · 187 participants
Moderate

Sildenafil vs placebo

Dropout · people with antidepressant‐induced sexual dysfunction

Sildenafil showed no clear difference in dropouts (People leaving the trial early) compared with placebo (high certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.68 [0.41, 1.14]
4 studies · 353 participants
High

Bupropion vs placebo

Endpoint scale total scores (150 mg twice daily dose) (Scales of sexual functioning. As studies used different scales to assess sexual functioning, differences are expressed as standardised mean differences (SMD)) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 482 participants
Moderate

Bupropion vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Bupropion showed no clear difference in 50% reduction in score on the Arizona Sexual Experiences Scale… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.62 [0.09, 4.41]
2 studies · 71 participants
Moderate