Findings

What do systematic reviews say?

2,447 questions · 2,590 findings · 266 reviews

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No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Psychological wellbeing ‐ post‐interventiond · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent–child relationship ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parenting skills; postintervention · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parent‐child relationship or assessment of parenting · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 153 participants
Low

Parenting interventions vs inactive control (usual care care, attention control, waitlist)

Parenting skills; postintervention · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 149 participants
Low

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Trauma‐related symptoms ‐ post‐interventionb · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 247 participants
Low

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Psychological wellbeing ‐ post‐interventiond · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

1 finding from 1 review

Interventions from pregnancy to two years after birth for parents experiencing complex post‐traumatic stress disorder… 2023 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 507 participants
Low

Sodium fluoride (NaF) varnish, applied every 3 months, plus OHI vs inactive control

Root carious lesions prevention · Older adults with root caries (community-dwelling or residential elders)

In elders, sodium fluoride varnish gave a 64% prevented fraction for root caries vs water, lower than SDF (71%) (p<0.01; ungraded).

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
36 months · Community/residential (older adults) · Tan 2010
Prevented Fraction 64
1 study · 306 participants
GRADE not reported

Clear aligners (Invisalign / thermoformed aligners) vs Conventional orthodontic appliance treatment

Salivary caries-associated bacteria (S. mutans and Lactobacilli, subjects with >10^5 CFU/mL) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)

Both included studies reported higher salivary caries-associated bacteria (S. mutans and Lactobacilli) with fixed appliances than clear aligners; not meta-analyzed (ungraded).

1 finding from 1 review

White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed… 2023 All outcomes
3 and 6 months · University/hospital orthodontic clinics and private practice (multiple countries)
Not meta-analyzed (insufficient number of studies). Both included observational studies (Mummolo 2020 [19]; Mummolo 2020 [25]) reported a higher number of subjects with S. mutans and Lactobacilli >10^5 CFU/mL in the…
2 studies
GRADE not reported

P11-4 + fluoride varnish vs CPP-ACFP

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…

P11-4 plus fluoride varnish did not differ significantly from CPP-ACFP (SMD -0.54, 95% CI -1.15 to 0.08; indirect evidence only); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD -0.54 [-1.15, 0.08]
Studies not reported
GRADE not reported

P11-4 + fluoride varnish vs Self-assembling peptide P11-4

P11-4 plus fluoride varnish did not differ significantly from P11-4 alone (SMD -0.40, 95% CI -0.97 to 0.17; indirect evidence only); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD -0.40 [-0.97, 0.17]
Studies not reported
GRADE not reported

Self-assembling peptide P11-4 vs Fluoride varnish

Self-assembling peptide P11-4 did not differ significantly from fluoride varnish (SMD -0.31, 95% CI -0.71 to 0.09); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD -0.31 [-0.71, 0.09]
5 studies
GRADE not reported

Self-assembling peptide P11-4 vs CPP-ACP

Self-assembling peptide P11-4 did not differ significantly from CPP-ACP (SMD -0.38, 95% CI -0.87 to 0.11; indirect evidence only); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD -0.38 [-0.87, 0.11]
Studies not reported
GRADE not reported

CPP-ACP vs CPP-ACFP

CPP-ACP did not differ significantly from CPP-ACFP (SMD 0.25, 95% CI -0.24 to 0.73); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
RCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesions
SMD 0.25 [-0.24, 0.73]
2 studies
GRADE not reported